Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM138152
Substrate
n/a
Meas. Tech.
Biological Assay
pH
3.5±n/a
Temperature
298.15±n/a K
IC50
>10000±n/a nM
Comments
extracted
Citation
 Chaplin, DJ; Gaddale Devanna, KK; Parker, E; Pinney, KG; Song, J; Trawick, ML Compositions and methods for inhibition of cathepsins US Patent  US8877967 Publication Date 11/4/2014 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM138152
Synonyms:
US8877967, 23
Type:
Small organic molecule
Emp. Form.:
C28H32N6O2S2
Mol. Mass.:
548.723
SMILES:
CC(C)Oc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC(C)C)cc1 |w:23.25,11.12|
Structure:
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