Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM138362
Substrate
n/a
Meas. Tech.
FP Assay
IC50
586±n/a nM
Citation
 Graef, IA; Alhamadsheh, M Identification of stabilizers of multimeric proteins US Patent  US8877795 Publication Date 11/4/2014 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM138362
Synonyms:
US8877795, 11
Type:
Small organic molecule
Emp. Form.:
C20H11N3O2
Mol. Mass.:
325.3202
SMILES:
O=C1C2C(Oc3[nH]c4ccccc4c3C2(C#N)C#N)c2ccccc12
Structure:
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