Reaction Details Report a problem with these data
Target
Pyruvate kinase PKM
Ligand
BDBM138389
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
90000±n/a nM
Citation
 Cantley, L; Vander Heiden, MG; Christofk, HR Inhibitors of pyruvate kinase and methods of treating disease US Patent  US8877791 Publication Date 11/4/2014 
Target
Name:
Pyruvate kinase PKM
Synonyms:
KPYM_HUMAN | OIP3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase (PKM2)
Type:
Protein
Mol. Mass.:
57944.31
Organism:
Homo sapiens (Human)
Description:
P14618
Residue:
531
Sequence:
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
  
Inhibitor
Name:
BDBM138389
Synonyms:
US8877791, H1
Type:
Small organic molecule
Emp. Form.:
C11H10N4O2
Mol. Mass.:
230.2227
SMILES:
O=C1C2C3CC(C=C3)C2C(=O)N1c1nc[nH]n1 |c:6|
Structure:
Search PDB for entries with ligand similarity: