Reaction Details Report a problem with these data
Target
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Ligand
BDBM285697
Substrate
n/a
Meas. Tech.
Calcineurin Phosphatase (CaN) Assay
IC50
304±n/a nM
Citation
 Pettit, SN; Jones, AD; Frydrych, CS; Thomas, AJ; Garst, ME Cyclosporins modified on the MeBmt sidechain by heterocyclic rings US Patent  US10077289 Publication Date 9/18/2018 
Target
Name:
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Synonyms:
CALNA3 | CAM-PRP catalytic subunit | CNA3 | Calcineurin, testis-specific catalytic subunit | Calmodulin-dependent calcineurin A subunit gamma isoform | PP2BC_HUMAN | PPP3CC
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58133.25
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
512
Sequence:
MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAEGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSIHAGGPMKSVTSAHSHAAHRSDQGKKAHS
  
Inhibitor
Name:
BDBM285697
Synonyms:
US10077289, Compound 5 | [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-5-(1-(pyridin-2-yl-methyl)-1H-imidazol-2-yl)-pentanoic acid]1 [(R)-methyl-Sar]3cyclosporin A
Type:
Small organic molecule
Emp. Form.:
C69H116N14O12
Mol. Mass.:
1333.7459
SMILES:
CC[C@H]1NC(=O)[C@@H]([C@H](O)[C@H](C)Cc2nccn2Cc2ccccn2)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)C |r|
Structure:
Search PDB for entries with ligand similarity: