Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM101761
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
270±n/a nM
Comments
extracted
Citation
 Fukuoka, M; Yokogawa, T; Miyahara, S; Miyakoshi, H; Yano, W; Taguchi, J; Takao, Y Anti-tumor effect potentiator US Patent  US8883759 Publication Date 11/11/2014 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Homo sapiens (Human)
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
  
Inhibitor
Name:
BDBM101761
Synonyms:
US8530490, 21
Type:
Small organic molecule
Emp. Form.:
C20H27N3O6S
Mol. Mass.:
437.51
SMILES:
O=c1ccn(COCCCS(=O)(=O)NCc2cccc(OC3CCCC3)c2)c(=O)[nH]1
Structure:
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