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TargetP70S6K (T412E)
LigandBDBM224426
Substrate/Competitorn/a
Meas. Tech.P70S6K Enzyme Assay
pH7.5±n/a
IC50 920±n/a nM
Commentsextracted
Citation Lan, RHuck, BRChen, XDeselm, LCQiu, HXiao, YNeagu, CMochalkin, IJohnson, TL Aminopyrimidine derivatives for use as modulators of kinase activity US Patent US10080750 Publication Date 9/25/2018
More Info.:Get all data from this article,  Assay Method
 
P70S6K (T412E)
Name:P70S6K (T412E)
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:59166.89
Organism:Homo sapiens (Human)
Description:n/a
Residue:525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM224426
NameBDBM224426
Synonyms:US10080750, Compound 103 | US9321760, 103 | US9662330, Compound 103
TypeSmall organic molecule
Emp. Form.C25H28F2N6
Mol. Mass.450.5268
SMILESNc1ncnc(N2CCN(CC2)[C@@H](CN2CCC2)c2cccc(F)c2)c1-c1ccc(F)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a