Reaction Details Report a problem with these data
Target
Ribosomal protein S6 kinase beta-1 [T412E]
Ligand
BDBM224462
Substrate
n/a
Meas. Tech.
P70S6K Enzyme Assay
pH
7.5±n/a
IC50
4.60±n/a nM
Comments
extracted
Citation
 Lan, R; Huck, BR; Chen, X; Deselm, LC; Qiu, H; Xiao, Y; Neagu, C; Mochalkin, I; Johnson, TL Aminopyrimidine derivatives for use as modulators of kinase activity US Patent  US10080750 Publication Date 9/25/2018 
Target
Name:
Ribosomal protein S6 kinase beta-1 [T412E]
Synonyms:
KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59166.89
Organism:
Homo sapiens (Human)
Description:
P23443[T412E]
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Inhibitor
Name:
BDBM224462
Synonyms:
US10080750, Compound 140 | US9321760, 140 | US9662330, Compound 140
Type:
Small organic molecule
Emp. Form.:
C22H22F2N4O
Mol. Mass.:
396.4331
SMILES:
Nc1ncnc(N2CCC(CC2)C(O)c2ccc(F)cc2)c1-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: