Target
Peptidyl-prolyl cis-trans isomerase G
Ligand
BDBM140006
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.8±n/a
Temperature
293.15±n/a K
IC50
3300±n/a nM
Comments
extracted
Citation
 Guichou, JColliandre, LAhmed-Belkacem, HPawlotsky, J Inhibitors of cyclophilins and uses thereof US Patent  US8901295 Publication Date 12/2/2014 
Target
Name:
Peptidyl-prolyl cis-trans isomerase G
Synonyms:
Cyclophilin A (CYPA) | PPIG | PPIG_HUMAN
Type:
Enzyme
Mol. Mass.:
88718.95
Organism:
Homo sapiens (Human)
Description:
Q13427
Residue:
754
Sequence:
MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDKSG
  
Inhibitor
Name:
BDBM140006
Synonyms:
US8901295, F712
Type:
Small organic molecule
Emp. Form.:
C25H34N4O2S
Mol. Mass.:
454.628
SMILES:
CSc1ccccc1C1CCCN1C(=O)C(CC(C)C)NC(=O)NCc1ccc(N)cc1
Structure:
Search PDB for entries with ligand similarity: