Reaction Details
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Peptidyl-prolyl cis-trans isomerase G
Ligand
BDBM140008
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.8±n/a
Temperature
293.15±n/a K
IC50
790±n/a nM
Comments
extracted
Citation
Guichou, J; Colliandre, L; Ahmed-Belkacem, H; Pawlotsky, J Inhibitors of cyclophilins and uses thereof US Patent US8901295 Publication Date 12/2/2014 More Info.:
Target
Name:
Peptidyl-prolyl cis-trans isomerase G
Synonyms:
Cyclophilin A (CYPA) | PPIG | PPIG_HUMAN
Type:
Enzyme
Mol. Mass.:
88718.95
Organism:
Homo sapiens (Human)
Description:
Q13427
Residue:
754
Sequence:
MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDKSG
Inhibitor
Name:
BDBM140008
Synonyms:
US8901295, F716
Type:
Small organic molecule
Emp. Form.:
C24H32N4O2S2
Mol. Mass.:
472.666
SMILES:
CSCCC(NC(=O)NCc1ccc(N)cc1)C(=O)N1CCCC1c1ccccc1SC
Structure:
