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Target
Beta-2 adrenergic receptor
Ligand
BDBM103752
Substrate
n/a
Meas. Tech.
cAMP assays
Temperature
298.15±n/a K
EC50
1.00±n/a nM
Comments
extracted
Citation
 Hughes, AD; Byun, D; Chen, Y; Fleury, M; Jacobsen, JR; Stangeland, EL; Wilson, RD; Yen, R Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity US Patent  US9682957 Publication Date 6/20/2017 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM103752
Synonyms:
US8551978, I-20 | US8816088, I-20 | US9394275, I-20 | US9572802, Compound I-20 | US9682957, I-20
Type:
Small organic molecule
Emp. Form.:
C46H54N6O7
Mol. Mass.:
802.957
SMILES:
CN(CCCCC(=O)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1)C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1 |r|
Structure:
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