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Target
Kappa-type opioid receptor
Ligand
BDBM285816
Substrate
n/a
Meas. Tech.
Radioligand Competition Binding Assay
pH
7.5±n/a
IC50
2682±n/a nM
Comments
extracted
Citation
 Duarte, FJ; Anand, NK; Sharma, P; Singh, D Opioid agonists and uses thereof US Patent  US10081602 Publication Date 9/25/2018 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM285816
Synonyms:
(2S, 6R, 11R)-3-(Cyclopropylmethyl)-8-({2-[2-(2-methoxy)ethoxy]ethyl}amino-6.11-dimethyl-3, 4, 5, 6-tetrahydro-2,6-methano-3-benzazocin-1(2H)-One (1) | US10081602, Example 1
Type:
Small organic molecule
Emp. Form.:
C26H40N2O4
Mol. Mass.:
444.6068
SMILES:
COCCOCCOCCNc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCCN3CC3CC3)c2c1 |r,THB:31:30:18:22.23.24.25,16:15:18:22.23.24.25,13:14:18:22.23.24.25|
Structure:
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