Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM141349
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.22±n/a nM
Citation
 Hayashi, K; Tamura, Y; Omori, N 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity US Patent  US8916594 Publication Date 12/23/2014 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mus musculus (Mouse)
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM141349
Synonyms:
US8916594, I-029
Type:
Small organic molecule
Emp. Form.:
C17H22F2N4O3S
Mol. Mass.:
400.443
SMILES:
CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccc(F)c(F)c1 |r,wU:7.6,wD:10.13,(-10.27,.87,;-8.93,.1,;-7.6,.87,;-8.37,2.21,;-6.83,2.21,;-6.27,.1,;-4.93,.87,;-3.6,.1,;-2.26,.87,;-.93,.1,;-.93,-1.44,;-2.26,-2.21,;-3.6,-1.44,;.4,-2.21,;1.74,-1.44,;3.2,-1.91,;4.11,-.67,;3.2,.58,;1.74,.1,;5.65,-.67,;6.42,-2,;7.96,-2,;8.73,-.67,;10.27,-.67,;7.96,.67,;8.73,2,;6.42,.67,)|
Structure:
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