Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM141359
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
3.1±n/a nM
Citation
 Hayashi, K; Tamura, Y; Omori, N 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity US Patent  US8916594 Publication Date 12/23/2014 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mus musculus (Mouse)
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM141359
Synonyms:
US8916594, I-145
Type:
Small organic molecule
Emp. Form.:
C13H21F3N4O3S
Mol. Mass.:
370.391
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C(F)(F)F |r,wU:8.7,wD:11.14,(-8.73,.87,;-7.39,.1,;-7.39,-1.44,;-6.06,.87,;-6.83,2.21,;-5.29,2.21,;-4.73,.1,;-3.39,.87,;-2.06,.1,;-.72,.87,;.61,.1,;.61,-1.44,;-.72,-2.21,;-2.06,-1.44,;1.94,-2.21,;3.28,-1.44,;4.74,-1.91,;5.65,-.67,;4.74,.58,;3.28,.1,;7.19,-.67,;7.96,.67,;7.96,-2,;8.73,-.67,)|
Structure:
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