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Target
EF-hand calcium-binding domain-containing protein 4B
Ligand
BDBM141446
Substrate
n/a
Meas. Tech.
In-Vitro Inhibition Assay
Temperature
310.15±n/a K
IC50
295.4±n/a nM
Comments
extracted
Citation
 Muthuppalaniappan, M; Viswanadha, S; Merikapudi, GS; Vakkalanka, SK Modulators of calcium release-activated calcium channel US Patent  US8921364 Publication Date 12/30/2014 
Target
Name:
EF-hand calcium-binding domain-containing protein 4B
Synonyms:
CRACR2A | Calcium release-activated calcium (CRAC) | EFC4B_HUMAN | EFCAB4B | RAB46
Type:
Protein
Mol. Mass.:
45570.29
Organism:
Homo sapiens (Human)
Description:
Q9BSW2
Residue:
395
Sequence:
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRCVGGHWPVLRAPPRSLGSEGPV
  
Inhibitor
Name:
BDBM141446
Synonyms:
US10668051, Compound Example 124 | US8921364, 124
Type:
Small organic molecule
Emp. Form.:
C18H12F5N5O
Mol. Mass.:
409.3128
SMILES:
Fc1cccc(F)c1C(=O)Nc1cnc(nc1)-n1nc(cc1C1CC1)C(F)(F)F
Structure:
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