Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha'
Ligand
BDBM142780
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
303.15±n/a K
IC50
0.93±n/a nM
Comments
extracted
Citation
 Purandare, AV; Fink, BE; Gavai, AV; Johnson, WL; Hart, AC; He, L; Huynh, TN; Inghrim, J; Mastalerz, H; Sang, X; Tarby, CM; Wan, H; Vaccaro, W; Zhang, G; Zhao, Y; Zimmermann, K Imidazotriazinecarbonitriles useful as kinase inhibitors US Patent  US8940736 Publication Date 1/27/2015 
Target
Name:
Casein kinase II subunit alpha'
Synonyms:
CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2)
Type:
Protein
Mol. Mass.:
41223.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
350
Sequence:
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
  
Inhibitor
Name:
BDBM142780
Synonyms:
US8940736, 60
Type:
Small organic molecule
Emp. Form.:
C27H30ClN11O2
Mol. Mass.:
576.053
SMILES:
COC(=O)N1CCC(CC1)N1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Structure:
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