Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-2
Ligand
BDBM144238
Substrate
n/a
Meas. Tech.
Radioligand Competition Binding Assay
Ki
23.9±n/a nM
Citation
 Omoto, K; Owen, RM; Pryde, DC; Watson, CA; Takeuchi, M Chemical compounds US Patent  US8952008 Publication Date 2/10/2015 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-2
Synonyms:
GABA receptor alpha-2 subunit | GABRA2 | GBRA2_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)
Type:
Protein
Mol. Mass.:
51338.78
Organism:
Homo sapiens (Human)
Description:
P47869
Residue:
451
Sequence:
MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
  
Inhibitor
Name:
BDBM144238
Synonyms:
US8952008, 31
Type:
Small organic molecule
Emp. Form.:
C22H21FN4O2S
Mol. Mass.:
424.491
SMILES:
CCS(=O)(=O)c1ccc(cc1)-c1cc(ccc1F)-c1cnnc2n(cnc12)C(C)C
Structure:
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