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Target
Tyrosine-protein kinase receptor
Ligand
BDBM144292
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
0.65±n/a nM
Citation
 Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent  US8969336 Publication Date 3/3/2015 
Target
Name:
Tyrosine-protein kinase receptor
Synonyms:
EML4 ALK Fusion Protein
Type:
Protein
Mol. Mass.:
87656.33
Organism:
Homo sapiens (Human)
Description:
A9YLN7
Residue:
796
Sequence:
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQAKMSTREKNSQVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
  
Inhibitor
Name:
BDBM144292
Synonyms:
US8969336, 370
Type:
Small organic molecule
Emp. Form.:
C30H43F3N8O2
Mol. Mass.:
604.71
SMILES:
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(c2)C(F)(F)F)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:39.43,wD:36.39,(6.72,.8,;6.72,-.74,;5.38,-1.51,;4,-.77,;2.67,-1.54,;1.58,-.45,;1.98,1.04,;.09,-.85,;2.67,-3.08,;1.33,-3.85,;,-3.08,;,-1.54,;-1.33,-.77,;-2.67,-1.54,;-4,-.77,;-4,.77,;-5.33,1.54,;-6.67,.77,;-6.67,-.77,;-5.33,-1.54,;-8,1.54,;-8,3.08,;-9.34,3.85,;-10.72,3.11,;-12.05,3.88,;-10.67,1.54,;-9.34,.77,;-2.72,-3.11,;-1.33,-3.85,;-4.05,-3.88,;-5.38,-4.65,;-3.28,-5.21,;-4.82,-2.54,;4,-3.85,;5.33,-3.08,;6.67,-3.85,;8,-3.08,;9.34,-3.85,;10.67,-3.08,;10.67,-1.54,;12,-.77,;9.34,-.77,;8,-1.54,)|
Structure:
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