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Target
Tyrosine-protein kinase receptor
Ligand
BDBM144295
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
0.23±n/a nM
Citation
 Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent  US8969336 Publication Date 3/3/2015 
Target
Name:
Tyrosine-protein kinase receptor
Synonyms:
EML4 ALK Fusion Protein
Type:
Protein
Mol. Mass.:
87656.33
Organism:
Homo sapiens (Human)
Description:
A9YLN7
Residue:
796
Sequence:
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQAKMSTREKNSQVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
  
Inhibitor
Name:
BDBM144295
Synonyms:
US8969336, 383
Type:
Small organic molecule
Emp. Form.:
C25H37N7O3
Mol. Mass.:
483.6064
SMILES:
CCc1nc(C(N)=O)c(Nc2ccc(OC)c(c2)N2CCN(C)CC2)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:31.34,wD:28.30,(4.72,3.31,;4.72,1.77,;3.38,1,;2,1.75,;.67,.98,;-.1,2.31,;.67,3.64,;-1.64,2.31,;.67,-.56,;-.67,-1.33,;-2,-.56,;-2,.98,;-3.33,1.75,;-4.72,1,;-6.05,1.77,;-7.38,1,;-4.67,-.56,;-3.33,-1.33,;-6,-1.33,;-7.34,-.56,;-8.67,-1.33,;-8.72,-2.9,;-10.05,-3.67,;-7.34,-3.64,;-6,-2.87,;2,-1.33,;3.33,-.56,;4.67,-1.33,;6,-.56,;7.34,-1.33,;8.67,-.56,;8.67,.98,;10,1.75,;7.34,1.75,;6,.98,)|
Structure:
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