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Target
Tyrosine-protein kinase receptor
Ligand
BDBM144306
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2.8±n/a nM
Citation
 Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent  US8969336 Publication Date 3/3/2015 
Target
Name:
Tyrosine-protein kinase receptor
Synonyms:
EML4 ALK Fusion Protein
Type:
Protein
Mol. Mass.:
87656.33
Organism:
Homo sapiens (Human)
Description:
A9YLN7
Residue:
796
Sequence:
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQAKMSTREKNSQVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
  
Inhibitor
Name:
BDBM144306
Synonyms:
US8969336, 491
Type:
Small organic molecule
Emp. Form.:
C32H50N8O2
Mol. Mass.:
578.7918
SMILES:
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(C)c2)nc1NC1CCC(O)(CC)CC1 |(-6.87,.46,;-5.54,-.31,;-4.2,.46,;-4.2,2,;-2.87,2.77,;-2.87,4.31,;-4.2,5.08,;-1.54,5.08,;-1.54,2,;-.2,2.77,;1.13,2,;2.46,2.77,;3.8,2,;3.8,.46,;5.13,-.31,;6.46,.46,;7.8,-.31,;7.8,-1.85,;6.46,-2.62,;5.13,-1.85,;9.13,-2.62,;10.47,-1.85,;11.8,-2.62,;11.8,-4.16,;13.13,-4.93,;10.47,-4.93,;9.13,-4.16,;2.46,-.31,;2.46,-1.85,;1.13,.46,;-1.54,.46,;-2.87,-.31,;-2.87,-1.85,;-4.2,-2.62,;-4.2,-4.16,;-5.54,-4.93,;-6.87,-4.16,;-7.69,-5.47,;-8.41,-4.22,;-9.13,-5.58,;-6.87,-2.62,;-5.54,-1.85,)|
Structure:
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