Reaction Details Report a problem with these data
Target
Phosphodiesterase
Ligand
BDBM144399
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
IC50
0.019±n/a nM
Comments
extracted
Citation
 Kawanishi, E; Hongu, M; Tanaka, Y Pyrazolopyrimidine compounds and their use as PDE10 inhibitors US Patent  US8969376 Publication Date 3/3/2015 
Target
Name:
Phosphodiesterase
Synonyms:
Phosphodiesterase 10A (PDE10A)
Type:
Protein
Mol. Mass.:
81617.01
Organism:
Bos taurus (Bovine)
Description:
F1MPW5
Residue:
711
Sequence:
WFGEEAWEGCSVARNLCPPYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCVFIPPGIKEGKPKLIPAGPIAQGTTTSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFRLSHQEVATANLAWASVAIHQVQVCRVFISRDVIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKLSGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTAEEWQGLMHFNLPGRLCKEIELFHFDVGPFENMWPGIFVYMIHRSCGTACFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNSRGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTRLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQIFPATEPLLKACRNNLSQWEKVIRGEESALGIPDLPEAEGSPERLPVKTDD
  
Inhibitor
Name:
BDBM144399
Synonyms:
US8969376, 1.050
Type:
Small organic molecule
Emp. Form.:
C26H33N7O2
Mol. Mass.:
475.5859
SMILES:
COCCN(CCCO)c1cc(nc2cc(nn12)-c1nc2cc(C)ccc2nc1C)N1CCCC1
Structure:
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