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Target
Phosphodiesterase
Ligand
BDBM144416
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
IC50
1.08±n/a nM
Comments
extracted
Citation
 Kawanishi, E; Hongu, M; Tanaka, Y Pyrazolopyrimidine compounds and their use as PDE10 inhibitors US Patent  US8969376 Publication Date 3/3/2015 
Target
Name:
Phosphodiesterase
Synonyms:
Phosphodiesterase 10A (PDE10A)
Type:
Protein
Mol. Mass.:
81617.01
Organism:
Bos taurus (Bovine)
Description:
F1MPW5
Residue:
711
Sequence:
WFGEEAWEGCSVARNLCPPYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCVFIPPGIKEGKPKLIPAGPIAQGTTTSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFRLSHQEVATANLAWASVAIHQVQVCRVFISRDVIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKLSGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTAEEWQGLMHFNLPGRLCKEIELFHFDVGPFENMWPGIFVYMIHRSCGTACFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNSRGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTRLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQIFPATEPLLKACRNNLSQWEKVIRGEESALGIPDLPEAEGSPERLPVKTDD
  
Inhibitor
Name:
BDBM144416
Synonyms:
US8969376, 1.154
Type:
Small organic molecule
Emp. Form.:
C24H27N7O2
Mol. Mass.:
445.5169
SMILES:
Cc1ccc2nc(C)c(nc2c1)-c1cc2nc(cc(NC3CCOCC3)n2n1)N1CC(O)C1
Structure:
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