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Target
Tyrosine-protein kinase SYK
Ligand
BDBM144502
Substrate
n/a
Meas. Tech.
Kinase Glo Luminescence Kinase Assay
IC50
1±n/a nM
Citation
 Hoffmann, M; Dahmann, G; Fiegen, D; Handschuh, S; Klicic, J; Linz, G; Schaenzle, G; Schnapp, A; East, SP; Mazanetz, MP; Scott, RJ; Walker, E Substituted naphthyridines and their use as medicaments US Patent  US8969568 Publication Date 3/3/2015 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM144502
Synonyms:
US8969568, 55
Type:
Small organic molecule
Emp. Form.:
C24H25N3O5
Mol. Mass.:
435.4724
SMILES:
COc1cc(ccc1O[C@@H]1CCOC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Structure:
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