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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM145683
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence Assay
Ki
10±n/a nM
Citation
 Chai, W; Dvorak, CA; Eccles, W; Edwards, JP; Goldberg, SD; Krawczuk, PJ; Lebsack, AD; Liu, J; Pippel, DJ; Sales, ZS; Tanis, VM; Tichenor, MS; Wiener, JJ 1,2,6-substituted benzimidazoles as FLAP modulators US Patent  US8952177 Publication Date 2/10/2015 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase-activating protein (FLAP) | A0A087WW23_HUMAN | ALOX5AP
Type:
Protein
Mol. Mass.:
24212.61
Organism:
Homo sapiens (Human)
Description:
A0A087WW23
Residue:
218
Sequence:
MLTFNHDAPWHTQKTLKTSEFGKSFGTLGHIGNISHQCWAGCAAGGRAVLSGEPEANMDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM145683
Synonyms:
US8952177, 37 | US8952177, 39 | US9089569, 39 | US9695149, 39
Type:
Small organic molecule
Emp. Form.:
C29H28N4O3
Mol. Mass.:
480.5576
SMILES:
Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1 |r|
Structure:
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