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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM149376
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
Temperature
303.15±n/a K
Ki
17.7±n/a nM
IC50
326±n/a nM
Comments
extracted
Citation
 Heiser, U; Sommer, R; Gaertner, U; Hamann, A; Almstetter, M; Thormann, M; Treml, A; Demuth, H; Hoffman, T Inhibitors of glutaminyl cyclase US Patent  US8962860 Publication Date 2/24/2015 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM149376
Synonyms:
US8962860, 43
Type:
Small organic molecule
Emp. Form.:
C17H12F2N4OS
Mol. Mass.:
358.365
SMILES:
Cc1ccc(C2N(C(=O)NC2=S)c2ccc3[nH]cnc3c2)c(F)c1F
Structure:
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