Reaction Details Report a problem with these data
Target
Uncharacterized protein
Ligand
BDBM50446181
Substrate
n/a
Meas. Tech.
Luminescent Kinase Assay
IC50
4.00±n/a nM
Citation
 Fan, E; Van Voorhis, WC; Zhang, Z; Huang, W; Ojo, KK 5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum US Patent  US9518026 Publication Date 12/13/2016 
Target
Name:
Uncharacterized protein
Synonyms:
Calmodulin-domain protein kinase (CDPK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60946.72
Organism:
Cryptosporidium parvum
Description:
n/a
Residue:
538
Sequence:
MGNTAVGNTGTRLRAPVDAVVNTTNKKAPVSEKPSQPQIPNKTSDVKKGGTMGGERGSVTTGMFVQSGSGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQAEKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDSNSLIQNEGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDKDGSGKISTKELFKLFSQADSSIQMEELESIIEQVDNNKDGEVDFNEFVEMLQNFVRNE
  
Inhibitor
Name:
BDBM50446181
Synonyms:
CHEMBL3108912 | US9518026, Example 1 | US9956214, Compound 1
Type:
Small organic molecule
Emp. Form.:
C18H20N4O
Mol. Mass.:
308.3776
SMILES:
CC(C)(C)n1nc(c(C(N)=O)c1N)-c1ccc2ccccc2c1
Structure:
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