Reaction Details Report a problem with these data
Target
Uncharacterized protein
Ligand
BDBM50446164
Substrate
n/a
Meas. Tech.
Luminescent Kinase Assay
IC50
21.0±n/a nM
Citation
 Fan, E; Van Voorhis, WC; Zhang, Z; Huang, W; Ojo, KK 5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum US Patent  US9518026 Publication Date 12/13/2016 
Target
Name:
Uncharacterized protein
Synonyms:
Calmodulin-domain protein kinase (CDPK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60946.72
Organism:
Cryptosporidium parvum
Description:
n/a
Residue:
538
Sequence:
MGNTAVGNTGTRLRAPVDAVVNTTNKKAPVSEKPSQPQIPNKTSDVKKGGTMGGERGSVTTGMFVQSGSGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQAEKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDSNSLIQNEGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDKDGSGKISTKELFKLFSQADSSIQMEELESIIEQVDNNKDGEVDFNEFVEMLQNFVRNE
  
Inhibitor
Name:
BDBM50446164
Synonyms:
CHEMBL3108995 | US9518026, Example 22 | US9956214, Compound 22
Type:
Small organic molecule
Emp. Form.:
C16H16N4O2
Mol. Mass.:
296.3238
SMILES:
NC(=O)c1c(N)n(CCO)nc1-c1ccc2ccccc2c1
Structure:
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