Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM150782
Substrate
n/a
Meas. Tech.
Cathepsin Ezyme Assay
pH
6±n/a
Ki
41±n/a nM
Comments
extracted
Citation
 Singh, M; Raghav, N 2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H. Bioorg Chem 59:12-22 (2015) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
36777.57
Organism:
Capra hircus (Goat)
Description:
n/a
Residue:
335
Sequence:
MWQLLATLSCLLVLTSARSSLHFPPLSDEMVNYVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADMVLPDSFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSKGRVNVEVSAEDMLTCCGSECGDGCNGGFPSGAWNFWTKKGLVSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPSYKDDKHFGCSSYSVSSNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEMMGGHAIRILGWGVENDTPYWLVGNSWNTDWGDKGFFKILRGQDHCGIESEIVAGMPCTHQY
  
Inhibitor
Name:
BDBM150782
Synonyms:
2-(4-Chlorophenyl)-2,3-dihydroquinazolin-4(1H)-one (1e)
Type:
Small organic molecule
Emp. Form.:
C14H11ClN2O
Mol. Mass.:
258.703
SMILES:
Clc1ccc(cc1)C1NC(=O)c2ccccc2N1
Structure:
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