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Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM286219
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
68.0±n/a nM
Citation
 Ali, A; Bennett, DJ; Cai, J; Carswell, E; Cooke, A; Hoyt, SB; Lo, M; London, C; MacLean, J; Park, MK; Ratcliffe, P; Taylor, JA; Whitehead, B; Xiong, Y Imidazopyridyl compounds as aldosterone synthase inhibitors US Patent  US9518055 Publication Date 12/13/2016 
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH
Type:
Enzyme
Mol. Mass.:
57591.44
Organism:
Homo sapiens (Human)
Description:
P15538
Residue:
503
Sequence:
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
  
Inhibitor
Name:
BDBM286219
Synonyms:
7-methyl-2-(6-methylpyridin-3- yl)-3-methylimidazo[1,2- a]pyridine | US9518055, Example 16
Type:
Small organic molecule
Emp. Form.:
C15H15N3
Mol. Mass.:
237.2997
SMILES:
Cc1c(nc2cc(C)ccn12)-c1cnccc1C
Structure:
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