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Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM286223
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2.20±n/a nM
Citation
 Ali, A; Bennett, DJ; Cai, J; Carswell, E; Cooke, A; Hoyt, SB; Lo, M; London, C; MacLean, J; Park, MK; Ratcliffe, P; Taylor, JA; Whitehead, B; Xiong, Y Imidazopyridyl compounds as aldosterone synthase inhibitors US Patent  US9518055 Publication Date 12/13/2016 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:
Protein
Mol. Mass.:
57582.15
Organism:
Homo sapiens (Human)
Description:
P19099
Residue:
503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
  
Inhibitor
Name:
BDBM286223
Synonyms:
6-fluoro-3-methyl-2-(4- methylpyridin-3-yl)imidazo[1,2- a]pyridine | US9518055, Example 20
Type:
Small organic molecule
Emp. Form.:
C14H12FN3
Mol. Mass.:
241.2636
SMILES:
Cc1c(nc2ccc(F)cn12)-c1cnccc1C
Structure:
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