Reaction Details Report a problem with these data
Target
Hepatic triacylglycerol lipase
Ligand
BDBM151428
Substrate
n/a
Meas. Tech.
Biological Assay
pH
8±n/a
Temperature
298.15±n/a K
IC50
7.3±n/a nM
Comments
extracted
Citation
 Finlay, H; Jiang, J; Kim, S; Parkhurst, B; Qiao, JX; Wang, TC; Pi, Z; Tora, GO; Lloyd, J; Johnson, JA Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase US Patent  US8987314 Publication Date 3/24/2015 
Target
Name:
Hepatic triacylglycerol lipase
Synonyms:
HL | HTGL | Hepatic Lipase (HL) | Hepatic lipase | Hepatic triacylglycerol lipase | LIPC | LIPC_HUMAN | Lipase member C
Type:
Protein
Mol. Mass.:
55938.55
Organism:
Homo sapiens (Human)
Description:
P11150
Residue:
499
Sequence:
MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR
  
Inhibitor
Name:
BDBM151428
Synonyms:
US8987314, B239
Type:
Small organic molecule
Emp. Form.:
C22H24F3N3O6S3
Mol. Mass.:
579.633
SMILES:
COCc1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)CCC(F)(F)F
Structure:
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