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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151946
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151946
Synonyms:
US8987457, 140
Type:
Small organic molecule
Emp. Form.:
C32H37F3N4O6S
Mol. Mass.:
662.72
SMILES:
C[C@H]1C[C@H](C[C@@H](N)[C@@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F |r,wU:3.15,1.0,5.5,wD:7.8,(-.87,.38,;-2.2,-.38,;-2.2,-1.93,;-3.53,-2.69,;-4.87,-1.93,;-4.87,-.38,;-6.2,.38,;-3.53,.38,;-3.53,1.93,;-4.87,2.69,;-4.47,4.18,;-5.8,4.95,;-7.14,4.18,;-6.57,6.29,;-5.03,6.29,;-3.53,-4.23,;-4.87,-5,;-4.87,-6.54,;-3.53,-7.31,;-2.2,-6.54,;-2.2,-5,;-.87,-4.23,;.47,-5,;.47,-6.54,;1.8,-4.23,;3.13,-5,;4.47,-4.23,;4.47,-2.69,;5.8,-1.92,;3.13,-1.93,;1.8,-2.69,;3.13,-.38,;1.8,.38,;.47,-.38,;1.8,1.93,;3.13,2.69,;3.13,4.23,;4.47,5,;5.8,4.24,;7.14,5,;7.14,6.54,;5.8,7.31,;4.47,6.54,;4.47,1.93,;4.47,.38,;5.8,-.38,)|
Structure:
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