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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151950
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151950
Synonyms:
US8987457, 144
Type:
Small organic molecule
Emp. Form.:
C28H31F3N4O5S
Mol. Mass.:
592.63
SMILES:
COc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)[C@H](OCCS(C)(=O)=O)[C@H](N)C1 |r,wU:26.28,28.31,38.41,30.33,(5.33,5.49,;4,4.72,;4,3.18,;2.67,2.41,;2.67,.87,;1.33,.1,;4,.1,;5.33,.87,;6.67,.1,;5.33,2.41,;4,-1.44,;2.67,-2.21,;2.67,-3.75,;4,-4.52,;5.33,-3.75,;5.33,-2.21,;6.67,-1.44,;1.33,-4.52,;1.33,-6.06,;,-3.75,;-1.33,-4.52,;-1.33,-6.06,;-2.67,-6.83,;-4,-6.06,;-4,-4.52,;-2.67,-3.75,;-2.67,-2.21,;-1.33,-1.44,;-1.33,.1,;,.87,;-2.67,.87,;-2.67,2.41,;-4,3.18,;-4,4.72,;-5.33,5.49,;-6.1,4.16,;-6.67,6.26,;-4.56,6.83,;-4,.1,;-5.33,.87,;-4,-1.44,)|
Structure:
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