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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM151872
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.73±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM151872
Synonyms:
US8987457, 66
Type:
Small organic molecule
Emp. Form.:
C26H25F3N8O2
Mol. Mass.:
538.5243
SMILES:
C[C@H]1CN(C[C@@H](N)[C@H]1n1cc(CO)nn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:5.5,1.0,7.8,(-.67,.56,;-2,-.21,;-2,-1.75,;-3.33,-2.52,;-4.67,-1.75,;-4.67,-.21,;-6,.56,;-3.33,.56,;-3.33,2.1,;-2.09,3.01,;-2.56,4.47,;-1.79,5.8,;-2.56,7.14,;-4.1,4.47,;-4.58,3.01,;-3.33,-4.06,;-4.67,-4.83,;-4.67,-6.37,;-3.33,-7.14,;-2,-6.37,;-2,-4.83,;-.67,-4.06,;.67,-4.83,;.67,-6.37,;2,-4.06,;3.33,-4.83,;4.67,-4.06,;4.67,-2.52,;6,-1.75,;3.33,-1.75,;2,-2.52,;3.33,-.21,;2,.56,;.67,-.21,;2,2.1,;3.33,2.87,;4.67,2.1,;4.67,.56,;6,-.21,)|
Structure:
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