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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM151893
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.68±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM151893
Synonyms:
US8987457, 87
Type:
Small organic molecule
Emp. Form.:
C23H21F3N8O
Mol. Mass.:
482.461
SMILES:
C[C@H]1CN(C[C@@H](N)[C@H]1N=[N+]=[N-])c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:5.5,1.0,7.8,(-.67,2.31,;-2,1.54,;-2,,;-3.33,-.77,;-4.67,,;-4.67,1.54,;-6,2.31,;-3.33,2.31,;-3.33,3.85,;-2,4.62,;-.67,5.39,;-3.33,-2.31,;-4.67,-3.08,;-4.67,-4.62,;-3.33,-5.39,;-2,-4.62,;-2,-3.08,;-.67,-2.31,;.67,-3.08,;.67,-4.62,;2,-2.31,;3.33,-3.08,;4.67,-2.31,;4.67,-.77,;6,,;3.33,,;2,-.77,;3.33,1.54,;2,2.31,;.67,1.54,;2,3.85,;3.33,4.62,;4.67,3.85,;4.67,2.31,;6,1.54,)|
Structure:
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