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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM151952
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.39±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM151952
Synonyms:
US8987457, 146
Type:
Small organic molecule
Emp. Form.:
C27H30F3N5O4S
Mol. Mass.:
577.618
SMILES:
C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F |r,wU:3.15,1.0,5.5,7.8,(,.87,;-1.33,.1,;-1.33,-1.44,;-2.67,-2.21,;-4,-1.44,;-4,.1,;-5.33,.87,;-2.67,.87,;-2.67,2.41,;-4,3.18,;-4,4.72,;-5.33,5.49,;-6.1,4.16,;-6.67,6.26,;-4.56,6.83,;-2.67,-3.75,;-4,-4.52,;-4,-6.06,;-2.67,-6.83,;-1.33,-6.06,;-1.33,-4.52,;,-3.75,;1.33,-4.52,;1.33,-6.06,;2.67,-3.75,;2.67,-2.21,;4,-1.44,;5.33,-2.21,;6.67,-1.44,;5.33,-3.75,;4,-4.52,;4,-6.06,;4,.1,;2.67,.87,;1.33,.1,;2.67,2.41,;4,3.18,;5.33,2.41,;5.33,.87,;6.67,.1,)|
Structure:
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