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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM151989
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.75±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM151989
Synonyms:
US8987457, 183
Type:
Small organic molecule
Emp. Form.:
C32H34F3N5O4
Mol. Mass.:
609.6387
SMILES:
C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F |r,wU:3.13,1.0,5.5,7.8,(-.67,.38,;-2,-.38,;-2,-1.93,;-3.33,-2.69,;-4.67,-1.93,;-4.67,-.38,;-6,.38,;-3.33,.38,;-3.33,1.93,;-4.67,2.69,;-4.67,4.23,;-6,5,;-7.34,5.78,;-3.33,-4.23,;-4.67,-5,;-4.67,-6.54,;-3.33,-7.31,;-2,-6.54,;-2,-5,;-.67,-4.23,;.67,-5,;.67,-6.54,;2,-4.23,;3.33,-5,;4.67,-4.23,;4.67,-2.69,;6,-1.92,;3.33,-1.93,;2,-2.69,;3.33,-.38,;2,.38,;.67,-.38,;2,1.93,;3.33,2.69,;3.33,4.23,;4.67,5,;6,4.23,;7.34,5,;7.34,6.54,;6,7.31,;4.67,6.54,;4.67,1.93,;4.67,.38,;6,-.38,)|
Structure:
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