Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 4
Ligand
BDBM286389
Substrate
n/a
Meas. Tech.
FLIPR Assay
Temperature
298.15±n/a K
IC50
4.35±n/a nM
Comments
extracted
Citation
Martel, A; Tremblay, F; Marinier, A; Priestley, ES; Posy, SL; Lawrence, RM; Miller, MM Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US9518064 Publication Date 12/13/2016
More Info.:
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
Inhibitor
Name:
BDBM286389
Synonyms:
2-Methoxy-6-(6-methoxy-4-((3′-(trifluoromethyl)-[1,1′-biphenyl]-3-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole | US9518064, Example 2
Type:
Small organic molecule
Emp. Form.:
C28H20F3N3O4S
Mol. Mass.:
551.536
SMILES:
COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cccc(c3)C(F)(F)F)cc(OC)cc2o1