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Target
Thymidine phosphorylase
Ligand
BDBM152493
Substrate
n/a
Meas. Tech.
Thymidine Phosphorylase Inhibition Assay
pH
7.4±n/a
IC50
6.397e+4± 7.3e+2 nM
Comments
extracted
Citation
 Shahzad, SA; Yar, M; Bajda, M; Shahzadi, L; Khan, ZA; Naqvi, SA; Mutahir, S; Mahmood, N; Khan, KM Synthesis, thymidine phosphorylase inhibition and molecular modeling studies of 1,3,4-oxadiazole-2-thione derivatives. Bioorg Chem 60:37-41 (2015) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TYPH_ECO57 | Thymidine phosphorylase (TP) | deoA
Type:
Protein
Mol. Mass.:
47171.52
Organism:
Escherichia coli (Enterobacteria)
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM152493
Synonyms:
5-(4'-Bromophenyl)-1,3,4-oxadiazole-2(3H)-thione (12)
Type:
Small organic molecule
Emp. Form.:
C8H5BrN2OS
Mol. Mass.:
257.107
SMILES:
Brc1ccc(cc1)-c1n[nH]c(=S)o1
Structure:
Search PDB for entries with ligand similarity: