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Target
Thymidine phosphorylase
Ligand
BDBM50134399
Substrate
n/a
Meas. Tech.
Thymidine Phosphorylase Inhibition Assay
pH
7.4±n/a
IC50
3.868e+4± 4.42e+3 nM
Comments
extracted
Citation
 Shahzad, SA; Yar, M; Bajda, M; Shahzadi, L; Khan, ZA; Naqvi, SA; Mutahir, S; Mahmood, N; Khan, KM Synthesis, thymidine phosphorylase inhibition and molecular modeling studies of 1,3,4-oxadiazole-2-thione derivatives. Bioorg Chem 60:37-41 (2015) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TYPH_ECO57 | Thymidine phosphorylase (TP) | deoA
Type:
Protein
Mol. Mass.:
47171.52
Organism:
Escherichia coli (Enterobacteria)
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM50134399
Synonyms:
1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7-Deazaxanthine (7DX) | 7-deazaxanthine | CHEMBL122899
Type:
Small organic molecule
Emp. Form.:
C6H5N3O2
Mol. Mass.:
151.1228
SMILES:
O=c1[nH]c2[nH]ccc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: