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Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM152612
Substrate
n/a
Meas. Tech.
Alpha-glucosidase Assay
pH
6.8±n/a
IC50
2.1985e+5± 1.12e+3 nM
Comments
extracted
Citation
 Rahim, F; Ullah, H; Javid, MT; Wadood, A; Taha, M; Ashraf, M; Shaukat, A; Junaid, M; Hussain, S; Rehman, W; Mehmood, R; Sajid, M; Khan, MN; Khan, KM Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of a-glucosidase. Bioorg Chem 62:15-21 (2015) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM152612
Synonyms:
(E)-4-(4-Chlorophenyl)-2-(2-(3-nitrobenzylidene)hydrazinyl)-thiazole (1)
Type:
Small organic molecule
Emp. Form.:
C16H11ClN4O2S
Mol. Mass.:
358.802
SMILES:
[O-][N+](=O)c1cccc(\C=N\Nc2nc(cs2)-c2ccc(Cl)cc2)c1
Structure:
Search PDB for entries with ligand similarity: