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Target
Acylase
Ligand
BDBM152688
Substrate
n/a
Meas. Tech.
PVdQ Inhibition Assay
pH
8±n/a
Ki
4.700e+6± 8.00e+5 nM
Comments
extracted
Citation
 Clevenger, KD; Wu, R; Liu, D; Fast, W n-Alkylboronic acid inhibitors reveal determinants of ligand specificity in the quorum-quenching and siderophore biosynthetic enzyme PvdQ. Biochemistry 53:6679-86 (2014) [PubMed]  Article 
Target
Name:
Acylase
Synonyms:
N-terminal nucleophile hydrolase (PVdQ)
Type:
Protein
Mol. Mass.:
84057.56
Organism:
Pseudomonas aeruginosa (g-Proteobacteria)
Description:
A0A0G5TC92
Residue:
762
Sequence:
MGMRTVLTGLAGMLLGSMMPVQADMPRPTGLAADIRWTAYGVPHIRAKDERGLGYGIGYAYARDNACLLAEEIVTARGERARYFGSEGKSSAELDNLPSDIFYAWLNQPEALQAFWQAQTPAVRQLLEGYAAGFNRFLREADGKTTSCLGQPWLRAIATDDLLRLTRRLLVEGGVGQFADALVAAAPPGTEKVALSGEQAFQVAEQRRQRFRLERGSNAIAVGSERSADGKGMLLANPHFPWNGAMRFYQMHLTIPGRLDVMGASLPGLPVVNIGFSRHLAWTHTVDTSSHFTLYRLALDPKDPRRYLVDGRSLPLEEKSVAIEVRGADGKLSRVEHKVYQSIYGPLVVWPGKLDWNRSEAYALRDANLENTRVLQQWYSINQASDVADLRRRVEALQGIPWVNTLAADEQGNALYMNQSVVPYLKPELIPACAIPQLVAEGLPALQGQDSRCAWSRDPAAAQAGITPAAQLPVLLRRDFVQNSNDSAWLTNPASPLQGFSPLVSQEKPIGPRARYALSRLQGKQPLEAKTLEEMVTANHVFSADQVLPDLLRLCRDNQGENSLARACAALAQWDRGANLDSGSGFVYFQRFMQRFAELDGAWKEPFDAQRPLDTPQGIALDRPQVATQVRQALADAAAEVEKSGIPDGARWGDLQVSTRGQERIAIPGGDGHFGVYNAIQSVRKGDHLEVVGGTSYIQLVTFPEEGPKARGLLAFSQSSDPRSPHYRDQTELFSRQQWQTLPFSDRQIDADPQLQRLSIRE
  
Inhibitor
Name:
BDBM152688
Synonyms:
1-Propylboronic acid (C3-B(OH)2)
Type:
Small organic molecule
Emp. Form.:
C3H9BO2
Mol. Mass.:
87.913
SMILES:
CCCB(O)O
Structure:
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