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Target
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Ligand
BDBM286538
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR) Assay
pH
7.4±n/a
Kd
1.60±n/a nM
Comments
extracted
Citation
 Fu, J; Karur, S; Li, X; Lu, P; Mergo, W; Rivkin, A; Sweeney, ZK; Tjandra, M; Weiss, A; Yifru, A Cyclic peptides and use as medicines US Patent  US9566312 Publication Date 2/14/2017 
Target
Name:
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Synonyms:
CYP3 | CyP-D | CyP-M | Cyclophilin D | Cyclophilin F | CypD | Mitochondrial cyclophilin | PPIF | PPIF_HUMAN | PPIase F | Rotamase F
Type:
PROTEIN
Mol. Mass.:
22052.60
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109465
Residue:
207
Sequence:
MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDVVKKIESFGSKSGRTSKKIVITDCGQLS
  
Inhibitor
Name:
BDBM286538
Synonyms:
US9566312, Compound 2.5.19
Type:
Small organic molecule
Emp. Form.:
C68H116F3N15O12
Mol. Mass.:
1392.7371
SMILES:
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H]([C@H](C)CN2CCn3c(C2)nnc3C(F)(F)F)N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)C |r|
Structure:
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