Reaction Details
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Acetylpolyamine amidohydrolase
Ligand
BDBM152728
Substrate
n/a
Meas. Tech.
APAH Fluorimetric Assay
pH
8.2±n/a
IC50
1.7e+2± 1e+1 nM
Comments
extracted
Citation
Decroos, C; Christianson, DW Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase. Biochemistry 54:4692-703 (2015) [PubMed] Article More Info.:
Target
Name:
Acetylpolyamine amidohydrolase
Synonyms:
APAH_MYCRA | Acetylpolyamine amidohydrolase (APAH) | Acetylpolyamine aminohydrolase | aph | aphA
Type:
Protein
Mol. Mass.:
36324.64
Organism:
Mycoplana ramosa (Gram-negative bacterium)
Description:
n/a
Residue:
341
Sequence:
MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG
Inhibitor
Name:
BDBM152728
Synonyms:
5-Amino-N-hydroxypentanamide (4)
Type:
Small organic molecule
Emp. Form.:
C5H13N2O2
Mol. Mass.:
133.1684
SMILES:
[NH3+]CCCCC(=O)NO
Structure:
