Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM152731
Substrate
n/a
Meas. Tech.
HDAC8 Fluorimetric Assay
pH
8.2±n/a
IC50
2.2e+3± 2e+2 nM
Comments
extracted
Citation
 Decroos, C; Christianson, DW Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase. Biochemistry 54:4692-703 (2015) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM152731
Synonyms:
8-Amino-N-hydroxypentanamide (7)
Type:
Small organic molecule
Emp. Form.:
C8H19N2O2
Mol. Mass.:
175.2481
SMILES:
[NH3+]CCCCCCCC(=O)NO
Structure:
Search PDB for entries with ligand similarity: