Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha [1-337]
Ligand
BDBM152738
Substrate
n/a
Meas. Tech.
Molecular Docking
IC50
0.5±0.0 nM
Citation
 Zhou, Y; Li, X; Zhang, N; Zhong, R Structural basis for low-affinity binding of non-R2 carboxylate-substituted tricyclic quinoline analogs to CK2a: comparative molecular dynamics simulation studies. Chem Biol Drug Des 85:189-200 (2015) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha [1-337]
Synonyms:
CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Protein Kinase CK2 (CK2α)
Type:
n/a
Mol. Mass.:
40183.44
Organism:
Homo sapiens (Human)
Description:
1-337 aa used
Residue:
337
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS
  
Inhibitor
Name:
BDBM152738
Synonyms:
5-(4-chlorophenyl)benzo[c]2,6-naphthyridine-8-carboxylic acid (Compound 12)
Type:
Small organic molecule
Emp. Form.:
C19H11ClN2O2
Mol. Mass.:
334.756
SMILES:
OC(=O)c1ccc2c(c1)nc(-c1ccc(Cl)cc1)c1ccncc21
Structure:
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