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Target
Prostaglandin G/H synthase 1
Ligand
BDBM152806
Substrate
n/a
Meas. Tech.
In vitro Cyclooxygenase Inhibition Assay
pH
8±n/a
Temperature
298.15±n/a K
IC50
1.1e+3±n/a nM
Comments
extracted
Citation
 Irannejad, H; Unsal Tan, O; Ozadali, K; Dadashpour, S; Tuylu Kucukkilinc, T; Ahangar, N; Ahmadnejad, M; Emami, S 1,2-Diaryl-2-hydroxyiminoethanones as dual COX-1 and ß-amyloid aggregation inhibitors: biological evaluation and in silico study. Chem Biol Drug Des 85:494-503 (2015) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68868.60
Organism:
Ovis aries (Sheep)
Description:
n/a
Residue:
600
Sequence:
MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
  
Inhibitor
Name:
BDBM152806
Synonyms:
(2E)-2-(4-fluorophenyl)-2-(N-hydroxyimino)-1-(4-methanesulfonylphenyl)ethan-1-one (5)
Type:
Small organic molecule
Emp. Form.:
C15H12FNO4S
Mol. Mass.:
321.323
SMILES:
CS(=O)(=O)c1ccc(cc1)C(=O)C(=N\O)\c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: