Reaction Details Report a problem with these data
Target
5,6-dihydroxyindole-2-carboxylic acid oxidase
Ligand
BDBM152928
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6.8±n/a
Temperature
310.15±n/a K
IC50
200±n/a nM
Comments
extracted
Citation
 Boiteau, J; Bouquet, K; Talano, S; Millois Barbuis, C 4-(azacycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and in cosmetics US Patent  US8993596 Publication Date 3/31/2015 
Target
Name:
5,6-dihydroxyindole-2-carboxylic acid oxidase
Synonyms:
TYRP1_MOUSE | Tyrosinase | Tyrp-1 | Tyrp1
Type:
Enzyme
Mol. Mass.:
60755.02
Organism:
Mus musculus (Mouse)
Description:
P07147
Residue:
537
Sequence:
MKSYNVLPLAYISLFLMLFYQVWAQFPRECANIEALRRGVCCPDLLPSSGPGTDPCGSSSGRGRCVAVIADSRPHSRHYPHDGKDDREAWPLRFFNRTCQCNDNFSGHNCGTCRPGWRGAACNQKILTVRRNLLDLSPEEKSHFVRALDMAKRTTHPQFVIATRRLEDILGPDGNTPQFENISVYNYFVWTHYYSVKKTFLGTGQESFGDVDFSHEGPAFLTWHRYHLLQLERDMQEMLQEPSFSLPYWNFATGKNVCDVCTDDLMGSRSNFDSTLISPNSVFSQWRVVCESLEEYDTLGTLCNSTEGGPIRRNPAGNVGRPAVQRLPEPQDVTQCLEVRVFDTPPFYSNSTDSFRNTVEGYSAPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYAYEVQWPGQEFTVSEIITIAVVAALLLVAAIFGVASCLIRSRSTKNEANQPLLTDHYQRYAEDYEELPNPNHSMV
  
Inhibitor
Name:
BDBM152928
Synonyms:
US8993596, Compound 48
Type:
Small organic molecule
Emp. Form.:
C19H21NO4
Mol. Mass.:
327.3743
SMILES:
O[C@H](C(=O)N1CCC(CC1)c1ccc(O)cc1O)c1ccccc1 |r|
Structure:
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