Target
Gag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N]
Ligand
BDBM5032
Substrate
Poly(rC):oligo(dG )Template:Primer
Meas. Tech.
HIV-1 RT Assay
pH
8.4±n/a
Temperature
310.15±n/a K
IC50
>50000±n/a nM
Citation
 Masuda, NYamamoto, OFujii, MOhgami, TFujiyasu, JKontani, TMoritomo, AOrita, MKurihara, HKoga, HKageyama, SOhta, MInoue, HHatta, TShintani, MSuzuki, HSudo, KShimizu, YKodama, EMatsuoka, MFujiwara, MYokota, TShigeta, SBaba, M Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives. Bioorg Med Chem 13:949-61 (2005) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N]
Synonyms:
EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (K103N)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [588-1147,K690N]
Synonyms:
HIV-1 Reverse Transcriptase Mutant (K103N) Chain A | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
64471.33
Organism:
Human immunodeficiency virus type 1
Description:
P04585[588-1147,K690N]
Residue:
560
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVL
  
Component 2
Name:
Gag-Pol polyprotein [588-1027,K690N]
Synonyms:
HIV-1 Reverse Transcriptase Mutant (K103N) Chain B | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
51280.01
Organism:
Human immunodeficiency virus type 1
Description:
P04585[588-1027,K690N]
Residue:
440
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYNLEKEPIVGAETF
  
Inhibitor
Name:
BDBM5032
Synonyms:
N-(5-tert-Butyl-3,4-dimethyl-1,3-thiazol-2(3H)-ylidene)-2-methoxybenzenesulfonamide | N-[(2Z)-5-tert-butyl-3,4-dimethyl-2,3-dihydro-1,3-thiazol-2-ylidene]-2-methoxybenzene-1-sulfonamide | thiazolidenebenzenesulfonamide deriv. 10f
Type:
Small organic molecule
Emp. Form.:
C16H22N2O3S2
Mol. Mass.:
354.487
SMILES:
COc1ccccc1S(=O)(=O)\N=c1/sc(c(C)n1C)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Poly(rC):oligo(dG )Template:Primer
Synonyms:
n/a
Type:
RNA /DNA Duplex
Mol. Mass.:
358.43
Organism:
n/a
Description:
The incorporation of Tritium-labeled [3H]dGTP onto a (poly)rC:(oligo)dG template:primer.
Residue:
3
Sequence:
NA