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Target
Membrane metallo-endopeptidase-like 1
Ligand
BDBM7494
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
38±n/a nM
Comments
extracted
Citation
 Foo, SY Method of treating contrast-induced nephropathy US Patent  US8993631 Publication Date 3/31/2015 
Target
Name:
Membrane metallo-endopeptidase-like 1
Synonyms:
Endopeptidase (NEP) | MELL1 | MMEL1 | MMEL1_HUMAN | MMEL2 | NEP2 | Neutral endopeptidase (NEP)
Type:
Enzyme
Mol. Mass.:
89358.76
Organism:
Homo sapiens (Human)
Description:
Q495T6
Residue:
779
Sequence:
MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW
  
Inhibitor
Name:
BDBM7494
Synonyms:
US8822534, 5-36 | US8822534, Example 5-1 | US8993631, 5-1
Type:
n/a
Emp. Form.:
C20H21NO5
Mol. Mass.:
355.3844
SMILES:
OC(=O)CCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1ccccc1
Structure:
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