Reaction Details Report a problem with these data
Target
Short-chain Z-isoprenyl diphosphate synthase
Ligand
BDBM153319
Substrate
n/a
Meas. Tech.
Radiometric Assay
IC50
4.4e+3±n/a nM
Citation
 Kim, MO; Feng, X; Feixas, F; Zhu, W; Lindert, S; Bogue, S; Sinko, W; de Oliveira, C; Rao, G; Oldfield, E; McCammon, JA A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery. Chem Biol Drug Des 85:756-69 (2015) [PubMed]  Article 
Target
Name:
Short-chain Z-isoprenyl diphosphate synthase
Synonyms:
ZFPP_MYCBO | cis-Farnesyl diphosphate synthase (cis-FPPS)
Type:
Protein
Mol. Mass.:
29475.52
Organism:
Mycobacterium tuberculosis H37Rv
Description:
Q7U0P8
Residue:
262
Sequence:
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPAFRHVDFLRALRDYSARHRRYGR
  
Inhibitor
Name:
BDBM153319
Synonyms:
BPH-1419
Type:
Small organic molecule
Emp. Form.:
C26H22Br2N2
Mol. Mass.:
522.274
SMILES:
NCCc1cc(Br)cc(c1)C#Cc1ccc(cc1)C#Cc1cc(Br)cc(CCN)c1
Structure:
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